Irwin Naturals EstroPause Menopause Support, 80 Liquid Softgels

What Irwin Naturals EstroPause Menopause Support is

Irwin Naturals EstroPause® Menopause Support is a supplement in liquid soft-gels with calcium, magnesium and black cohosh, plus fish oil, St. John’s Wort, soy isoflavones, red clover, Asian ginseng and vitex (chasteberry): each 4-softgel serving has 500 mg of calcium and 200 mg of magnesium, and the bottle holds 80. The label says 2 to 4 a day with meals, so the bottle lasts 20 to 40 days (our math). It costs $28.80, about $0.36 per softgel (our math). Free shipping in Puerto Rico on orders from $35, or pick it up at our store in Galería Paseos.

The front of the bottle says «Calcium · Magnesium · Black Cohosh» and «Promotes Female Health Throughout All Stages of Menopause*». The side says it is formulated specifically for aging women: «EstroPause® Menopause Support* is formulated specifically for aging women.*» It also says: «Female Support*: Menopause is a natural stage of life that all women must go through. To make the transition smoother and easier, many women require additional support.*» and «Botanicals: This multi-approach formula contains women’s health herbs, including Black Cohosh, Chasteberry (Vitex) and Red Clover. Ginseng has been traditionally used as a revitalizing tonic.*»

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Its ingredients and what they do in the body

Calcium, 500 mg per serving (38% of the Daily Value), as calcium carbonate and calcium citrate. It is a mineral. According to MedlinePlus, from the U.S. National Library of Medicine, it is the most plentiful mineral in the body: the body stores almost all of its calcium in the bones and teeth to keep them strong, and also uses it to help the muscles move and to help the nerves carry messages between the brain and the rest of the body. The label says: «Calcium and Magnesium are two of the most important minerals for pre-menopausal women and support the structure and function of bones, muscles and nerves.*»

What sets it apart:

It has calcium in its two main supplement forms, carbonate and citrate, as the panel shows. MedlinePlus explains that calcium carbonate is absorbed better when taken with food and that calcium citrate is absorbed well on an empty or a full stomach. The label says to take EstroPause with meals.

Magnesium, 200 mg per serving (48% of the Daily Value), as magnesium oxide and magnesium citrate. It is another mineral. MedlinePlus explains that the body needs it for more than 300 biochemical reactions, that it helps maintain normal muscle and nerve function, keeps the heartbeat steady, helps bones remain strong and aids in the production of energy and protein (reviewed January 2025).

Black cohosh root extract, 80 mg per serving, with 2.5% triterpenoid saponins (2 mg). According to the NIH National Center for Complementary and Integrative Health (NCCIH), in its fact sheet updated November 2024, it is a member of the buttercup family that grows in North America; the root or rhizome (underground stem) is used, it has been used medicinally in Germany since the late 19th century. It is one of the three ingredients the front of the bottle highlights.

Fish oil, 2,158 mg per serving, with 30% omega-3 (647 mg), from anchovy and sardine. NCCIH explains that EPA and DHA, the most studied omega-3s, are found in cold-water fish and in fish oil supplements. MedlinePlus explains that omega-3 fats are essential fatty acids the body needs for cell growth and brain function, and that the body does not make them.

St. John’s Wort aerial extract, 300 mg per serving, with 0.3% hypericin (0.9 mg). According to NCCIH (May 2025 fact sheet), it is a plant with yellow flowers used in traditional Greek, Islamic and Chinese medicine; the name refers to John the Baptist, because it blooms in late June. NCCIH also explains that it has been clearly shown that it can interact with many medicines, which is why the label warns about it (see the warnings).

Soy isoflavones, 100 mg per serving, with 5% total isoflavones (5 mg). According to NCCIH (April 2025), isoflavones are compounds in soy with a structure similar to the hormone estrogen.

Red clover aerial powder, 40 mg per serving. NCCIH (April 2025) explains that it is a legume, like peas and beans, native to Europe, central Asia and northern Africa, and that it also contains isoflavones with a structure similar to estrogen. It adds that research in people is not yet conclusive.

Asian ginseng root extract, 31 mg per serving. According to NCCIH (February 2025), it is native to Korea, northeastern China and far-eastern Siberia; the root is the part used most, and its most important compounds are called ginsenosides. NCCIH adds that traditional Chinese medicine has used it as a calming agent and as an adaptogen. The label says ginseng has been traditionally used as a revitalizing tonic*.

Vitex (chasteberry, Vitex agnus-castus) 10:1 fruit extract, 20 mg per serving. According to NCCIH (April 2025), it is a shrub native to the Mediterranean and Central Asia. The label names it, with black cohosh and red clover, among its «women’s health herbs»*.

BioPerine® Complex, 6 mg per serving: BioPerine® black pepper fruit extract (95% piperine) and ginger rhizome extract (5% gingerols). The label says: «Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.*»

These explanations describe normal body functions; they are not results measured with this product.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Label facts

Label facts for this bottle, confirmed with the package image registered in the NIH Dietary Supplement Label Database (DSLD 292070), with the same barcode.

** Percent Daily Values are based on a 2,000 calorie diet. † Daily Value not established.

• Contents: 80 liquid soft-gels; serving size 4 softgels; 20 servings.
• Other ingredients: gelatin, purified water, glycerin, soy lecithin, titanium dioxide (color), beeswax, lycopene (color) and maltodextrin. No preservatives added.
• Allergens: contains fish (anchovy, sardine) and soy.
• Distributed by: Irwin Naturals, Los Angeles, CA 90066, USA. Barcode 710363262440.

How to take it

The label says, for adults, 2 to 4 liquid soft-gels a day with meals and a full glass (8 oz) of water. They may be taken all at once or divided throughout the day. At 4 a day the 80-softgel bottle lasts 20 days (about $1.44 a day); at 2 a day, 40 days (about $0.72 a day) (our math). The label says not to exceed 90 days of continuous use without a 2-week break. Store in a cool, dry place.

Warnings

• Do not use if safety seal is broken.
• St. John’s Wort can interact with medications, such as antidepressants, heart medications, blood thinners, immunosuppressants, and other medications.
• Avoid excessive sun exposure as use of this product may cause your skin to be extra sensitive to UV sources.
• This product contains an ingredient that may affect blood sugar.
• Check with your doctor before using this product if you are using medication or have any medical conditions, including heart disease and/or high/low blood pressure.
• Do not exceed 90 days of continuous use of this product without a two (2) week break.
• Do not use if you may become pregnant, are pregnant, nursing, or taking contraceptives.
• Do not exceed recommended daily intake.
• Not intended for use by persons under 18.
• Keep out of reach of children.
• Contains fish (anchovy, sardine) and soy.

Frequently asked questions

What is EstroPause Menopause Support for?

According to the label, it promotes female health throughout all stages of menopause* and is formulated specifically for aging women*. It combines calcium and magnesium, which the label says support the structure and function of bones, muscles and nerves*, with black cohosh, vitex and red clover. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

How do you take EstroPause?

Adults: 2 to 4 liquid soft-gels a day with meals and a full glass (8 oz) of water, all at once or divided throughout the day. The label says not to exceed 90 days of continuous use without a 2-week break.

How long does the 80-softgel bottle last?

From 20 days (4 a day) to 40 days (2 a day) (our math).

Does it contain fish or soy?

Yes. The label says it contains fish (anchovy, sardine) and soy, and the softgel is made of gelatin.

Can I take it if I use contraceptives or medications?

With contraceptives, no: the label says not to use it if you are taking contraceptives, may become pregnant, are pregnant or nursing. If you take other medications, check with your doctor first: St. John’s Wort can interact with antidepressants, heart medications, blood thinners, immunosuppressants and others.

Where can I buy EstroPause in Puerto Rico and how much is it?

At Borinquen Natural, for $28.80 per 80-softgel bottle, about $0.36 per softgel (our math). Free shipping in Puerto Rico on orders from $35, or pick it up at our store in Galería Paseos.

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